SNP 45(T/G) of adiponectin gene polymorphism and genetic susceptibility to type 2 diabetes mellitus
- VernacularTitle:脂联素基因+45位T/G多态性与2型糖尿病遗传易感性的相关性
- Author:
Yingli WEI
;
Lanjie HE
;
Zhenghao HUO
;
Wei ZHAO
- Publication Type:Journal Article
- Keywords:
type2 diabetes;
adiponectin;
gene;
single nucleotide polymorphisms;
genetic susceptibility
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation of single nucleotide polymorphisms (SNP)45T/G the adiponectin gene with type 2 diabetes of Han nationality in Ningxia.Methods PCR-RFLP method was used to identify the distribution of alleles and genotypes frequencies of SNP45T/G polymorphisms in adiponectin gene in 100 type 2 diabetic patients and 101 normal subjects.Results The distribution of genotypes and alleles frequencies of the SNP45 polymorphisms were significantly different (GG genotype:13% vs 3%,P
