Molecular characteristics of leukemia stem cells and up-dating therapeutic strategy
- VernacularTitle:白血病干细胞分子生物学特性及其治疗策略研究进展
- Author:
Ying GU
;
Xi QIU
;
Rongzhen XU
- Publication Type:Journal Article
- Keywords:
leukemia stem cell;
relapse;
drug resistance
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Drug resistance and relapse are two major causes for treatment failure of leukemia, but their mechanisms remain elusive. Recently, increasing evidence shows that there is a subset of leukemia stem cells apart from immature leukemia cells in leukemia patients. These malignant stem cells do not response to routine chemotherapeutic agents, and may be the source of drug resistance and relapse of leukemia. Permanent cure of leukemia need elimination of these leukemia stem cells. We describe molecular characteristics of leukemia stem cells and possible target therapeutic strategies in this review.
