Tumor stem cells and targeting cancer therapy
- VernacularTitle:肿瘤干细胞与肿瘤靶向治疗
- Author:
Shuli WEI
;
Shineng ZHANG
- Publication Type:Journal Article
- Keywords:
tumor stem cells;
self-renewal;
miRNAs;
targeting therapy
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The hypothesis of tumor stem cells believes that a small proportion of cells which have the stemness property reside in tumor. This population is the cause of tumor formation, growth, metastasis and relapse. Only the therapy targeting this population could make tumors curable. At present, most anti-cancer protocols only kill the majority of differentiated tumor cells and hardly affect the tumor stem cells. That is why most of the therapies do not achieve good results. Disrupting the pathways and niche which regulate the tumor stem cells’ self-renewal, or inducing the tumor stem cells’ differentiation, or targeting the surface markers which distinguish the tumor stem cells from normal stem cells are all probable strategies.
