Detection and of CD5-positive B cells in peripheral blood mononuclear cells of patients with chronic HCV infection and its clinical significance
- VernacularTitle:慢性丙型肝炎患者外周血CD5~+ B细胞检测及意义
- Author:
Haiyan YOU
;
Zhijun JIAO
;
Renlian DIAO
;
Lei CHEN
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
hepatitis C virus(HCV);
CD5 molecule;
B cells
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the percentage of CD5-positive B cells in peripheral blood mononuclear cells(PBMC) of patients with chronic HCV infection and its clinical significance.Methods The expression of CD5 molecule on B cell surface was detected by flow cytometry and HCV RNA copies were detected by real-time PCR.Results The percentage of CD5+-B cells significantly increased in the patients with chronic HCV infection(58.4%?9.8%) compared with healthy controls(22.5%?5.9%)(P
