Significance of determination for binding ratio of L-PHA with serum alkaline phosphatase in diagnosis of liver cancer
- VernacularTitle:血清碱性磷酸酶红腰豆凝集素结合率测定在肝癌诊断中的意义
- Author:
Guoqian CHEN
;
Chunxin WANG
;
Zhigang HU
;
Xiaofei CHEN
- Publication Type:Journal Article
- Keywords:
alkaline phosphatase;
lectin;
sugar chain;
primary hepatic cancer
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of determination for binding ratio of L-PHA(leukoagglutinating phytohemagglutinin) with serum alkaline phosphatase in the diagnosis of primary hepatic cancer.Methods The binding ratios of L-PHA with serum alkaline phosphatase in 50 healthy individuals,103 cases of primary hepatic cancer,22 cases of hepatocirrhosis,36 cases of chronic hepatitis,18 cases of acute hepatitis and 13 cases of digestive tract tumor were determined by lectin affinity chromatography.Results The binding ratio of L-PHA with serum alkaline phosphatase in primary hepatic cancer(16.01% 5.42%) were significantly increased as compared with the healthy control(7.50% 2.53%)(P 0.01).The binding ratios were positively correlated with the tumor size and AFP level.Conclusion The binding ratio of L-PHA with serum alkaline phosphatase is a potential parameter for the laboratory diagnosis of primary hepatic cancer.
