Bioactive alkaloids from sponge-derived actinomyces sh6004
- VernacularTitle:海绵来源放线菌sh6004发酵产物中的活性生物碱
- Author:
Haichao FU
- Publication Type:Journal Article
- Keywords:
spong-derived actinomyces;
antimicrobial;
antitumor;
alkaloids;
actinomycins
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To isolate and identify the antitumor components of the fermentation of the actinomyces sh6004 derived from a piece of sponge(unidentified)collected in Jiaozhou Bay.Methods The antitumor components were isolated by bioassay-guided fractionation and using solvent extraction,silica gel column chromatography and preparative HPLC.Their structures were established by physicochemical properties and spectral analyses.The cyto- toxicity of compound 4 and the antimicrobial activities of compounds were evaluated by SRB and paper disc method,respectively.Results and Conclusion Four alkaloid compounds were i- solated and identified as bisdethiobis-(methylthio)-gliotoxin(1),actinomycin D(2),actino- mycin C_(2a)(3)and aetinomycin C_3(4),respectively.Actinomycins were the main antitumor components produced by actinomyces sh6004.Compounds 1～4 showed antimicrobial activi- ties against Staphylococcus aureus and Bacillus subtilis at a concentration of 10?g?mL~(-1).
