Peroxynitrite aggravates myocardium injury in acute myocardial infarction during ischemia-reperfusion
- VernacularTitle:过氧亚硝酸阴离子加重急性心肌梗死患者缺血-再灌注心肌损伤
- Author:
Lin LIU
;
Qian FAN
;
Xinchun YANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Myocardial reperfusion injury;
Peroxynitrous acid
- From:
Chinese Journal of Interventional Cardiology
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of peroxynitrite(ONOO-)in acute myocardial infarction during ischemia-reper fusion.Methods Thirty patients with actute myocardial infarction(single coronary arterial stenosis of left anterior descending in proximal-middle segment) and twenty-four healthy cases were enrolled as the control in our research.Peripheral blood were taken at the time of 24 h and 72 h after primary percutaneous coronary intervention.The patients were further divided into 2 groups according to their serum cTnI level(mild myocardium injury group with cTnI 0.05).Conclusion Plasma peroxynitrite(ONOO-) is related to myocardium injury during ischemia-reperfusion in actue myocardial infarction which suggest that peroxynitrite may aggravate myocardium injury in acute myocardial infarction during ischemia-reperfusion.
