Feature of distribution of vesicular monoamine transporter in human embryonic brain and their relationship with Parkinson's disease
- VernacularTitle:囊泡单胺转运体在人胚胎脑组织中的分布特征及其与帕金森病的关系
- Author:
Xiangyang TIAN
;
Xinsheng DING
;
Min MIN
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
VMAT2;
immunohistochemistry;
tyrosine hydroxylase;
human embryo
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feature of distribution of vesicular monoamine transporter(VMAT2) in human embryonic brains and their relationships with Parkinson disease.Methods The distribution of VMAT2 and tyrosine hydroxylase (TH) in substantia nigra pars compacta(SNC), ventral tegmental ares(VTA) and locus coeruleus(LC) were examined by immunohistochemical staining and Western blot in human spontaneous abortion embryonic brains of different gestational age.Results The distribution of VMAT2 in SNc was less than that in both VTA and LC(all P
