Expression of GABA_B recepter subunit in hippocampus and effect of its agonist after experimental epileptic rats
- VernacularTitle:实验性癫癎大鼠发作后海马?-氨基丁酸B受体亚单位的表达及其激动剂的影响
- Author:
Jihong TANG
;
Shiyao BAO
;
Zhilin ZHANG
- Publication Type:Journal Article
- Keywords:
temporal lobe epilepsy;
GABAB receptor;
hippocampus;
kainic acid
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Gamma-aminobutyric acid B recepter (GABABR) subunits mRNA and the effects of its agonist Baclofen in hippocampus after KA induced seizures,of experimental epileptic rats.Methods The GABABR subunits GAR1a及GAR2 mRNAs expression were determined in hippocampus of each experimental group after epileptic seizure and Baclofen interference by hybridization in situ. Results In early(6~12 h) time of KA induced epileptic rats, the mRNA levels of both receptor subunits in hippocampal formation were found downregulation widespreadly (all P
