Roles of integrin and vascular endothelial growth factor in angiogenesis
- VernacularTitle:整合素和血管内皮生长因子在血管新生中的作用
- Author:
Wei SHANG
;
Hui CAI
- Publication Type:Journal Article
- Keywords:
Integrin;
Vascular endothelial growth factor;
Angiogenesis
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Integrin is a main factor that mediates adhesive attraction between the cell and the extracellular matrix,and it participates in the formation of new vessel lumens and the construction of the rete vasculosum by regulating endothelial cell adhesion and migration.The extracellular matrix is the ligand of integrin.Collagen and laminin's deposition form new vessel lumens.The vascular endothelial growth factor promotes the proliferation of endothelial cells,accelerates angiogenesis and increases the permeability of blood vessels.This review focuses on the roles and correlation of integrin and VEGF in angiogenesis.
