Expression and clinical application of aromatasecy P450 and receptor of estrogen and progesterone in the tissue of endometrial cancinoma
- VernacularTitle:芳香化酶P450及雌激素和孕激素受体在子宫内膜癌发生发展过程中的表达及意义
- Author:
Yan XING
;
Shuyu WANG
;
Lizhou SUN
- Publication Type:Journal Article
- Keywords:
Endometrial hyperplasia;
Endometrial carcinoma;
Aromatase P450;
Estrogen receptor;
Progesterone receptor
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of aromatasecy P450 and receptor of estrogen and progesterone in the tissue of endometrial hyperplasia and endometrial cancinoma,analysis the correlation of the endometrial carcinoma pathogenesis,clinical stage and cell differentiation.Methods:The immunohistochemiscal S-P method techniques were performed to study the expression of aromatasecy P450,estrogen receptor(ER) and progesterone receptor(PR) in the tissue of endometrium from 226 cases,including 42 cases of normal endometrium,52 cases of simple endometrial hyperplasia,38 cases of complex endometrial hyperplasia,36 cases of endometrial atypical hyperplasia and 58 cases of endometrial carcinoma.Results:There was no the positive expression in the normal endometrial tissues.But the positive expressions of aromatasecy P450 were found in the tissue of endometrial hyperplasia(simple endometrial hyperplasia,complex endometrial,atypical hyperplasia)and endometrial carcinoma.The rates of the positive expression were 40.4%,47.4%,69.4%,72.4% respectively.There were significant relationships among fifth groups(P
