Location of skin stem cells
- VernacularTitle:皮肤干细胞的定位
- Author:
Shanshan HUANG
;
Qing WANG
;
Li LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
Pubmed (1990-2008) and China Journal Full-text Database (CJFD) (1998-2008) were searched for relevant articles on localization of skin stem cells. A total of 44 articles revealed that hair follicle bulge cells that are label-retaining cells regenerate themselves by division and can give rise to differentiated progeny. They did not express characteristic markers of differentiated cells, but stem cells markers. Therefore hair follicle bulge region was considered to be epidermal stem cells niche. Hair follicle dermal sheath housed multipotent and plastic stem cells, considered to be dermal stem cells niche. Hair follicle dermal papilla interacted with dermal sheath to induce the formation of hair follicle. It is believed that precursor cells in dermal papilla harvested from dermal sheath stem cells are the active daughter cells. Whether skin stem cells are present in hair follicle and hairless region is under debate. Some studies found that skin stem cells were detected in the basal layer of epidermis in hair follicle.
