Embryonic stem cell differentiation towards cardiomyocytes and its application in cardiac tissue engineering
- VernacularTitle:胚胎干细胞向心肌诱导分化及其在心脏组织工程中的应用
- Author:
Dongbo OU
;
Qiangsun ZHENG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
Embryonic stem cells (ESCs) show potential prospect of wide application in establishing cardiac pharmacological model system, forming three-dimensional cardiac tissues and constructing biological pacemaker. The process of ESCs differentiating into cardiomyocytes is to simulate heart growth and development in vitro. The cases of transplanting ESCs into animal models confirm that the cardiac function is improved. Moreover, the research and exploitation of tissue engineered cardiac muscle tissue with vessel system brings hope for clinical cardiac muscle restoration. ESC-derived pacemaker can functionally integrate with quiescent ventricular muscle cells to induce rhythmic electrical and contractile activities in vitro. However, the immunological rejection limits its clinical application. Although ESCs have strong differentiation potential, the problems such as the differentiation process towards cardiomyocytes, ESC induction and signal regulatory pathway, and whether induced cardiomyocytes can substitute in vivo cardiomyocytes still need exploration.
