Expression of MCM4 and CDC6 in uterine cervical carcinoma and its relation with HPV_(16/18) infection
- VernacularTitle:宫颈癌组织中MCM4、CDC6的表达及其与HPV_(16/18)感染的相关性
- Author:
Liping CHEN
;
Runhua LIU
;
Fuxi ZHAO
- Publication Type:Journal Article
- Keywords:
uterine cervical carcinomas;
minichromosome maintenance proteins 4(MCM4);
cell division cycle 6(CDC6);
human papillomavirus(HPV)
- From:
Chinese Journal of Cancer Biotherapy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of minichromosome maintenance proteins 4(MCM4)and cell division cycle 6(CDC6)in uterine cervical carcinomas and its relationship with human papilloma virus(HPV)16/18 infection.Methods:The expression of MCM4 and CDC6 was examined in 50 squamous cell carcinoma specimens,20 cervical intraepithelial neoplasia(CIN)Ⅱ-Ⅲ specimens,20 CINⅠ specimens,and 20 normal cervical tissues by immunohistochemical method.The infections of HPV type 16,18 DNA were determined by PCR.Results:(1)The expression of MCM4 and CDC6 in uterine cervical carcinoma tissues was significantly higher than that in the CIN specimens and normal cervical tissues(Both P0.05).(2)The positive rates of(HPV)16/18 were significant different between cervical carcinomas,CIN and normal tissues(P0.05).(3)MCM4 expression were positively correlated with the expression of CDC6 in uterine cervical carcimonas(r=0.390,P
