Blood glucose control improves myocardial glucose metabolism in diabetic rats
- VernacularTitle:控制血糖促进糖尿病大鼠心肌葡萄糖代谢
- Author:
Xiaolin CHEN
;
Zhongyuan WEN
;
Teng WANG
;
Yong WU
- Publication Type:Journal Article
- Keywords:
type 2 diabetes;
myocardium;
glucose metabolism;
GLUT4
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of glycemic control on myocardial glucose metabolism in type 2 diabetic rats. Methods Eighteen male Sprague-Dawley rats were divided into three groups:control, diabetes, therapy.Fed with high-fat diet and intraperitoneally injected with streptozotocin to establish type 2 diabetic model,the rate of carbohydrate oxidation was measured by isolated heart Langendorf perfusion apparatus, the expression level of glucose transport 4(GLUT4) was measured by Western blotting. Results Compared with the control group,the diabetic rats had a significantly depression of glucose uptake in the hearts(P
