Change in blood flow of rats with diabetes mellitus after the acute hind limb ischemia
- VernacularTitle:糖尿病大鼠模型急性下肢缺血的血流变化
- Author:
Yuming ZHAO
;
Kexin SONG
;
Xiaoqing YAN
;
Lei YOU
;
Jun XU
- Publication Type:Journal Article
- Keywords:
rat;
diabetic mellitus;
hind limb ischemia;
laser doppler perfusion imager
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the acute hind limb ischemia on Wistar rat with diabetes mellitus.MethodsThirty diabetes rats were induced by intraperitoneal STZ (50 mg/kg) injection, as well as the blood glucose level tested over 16.8 mmol/L. The rats were ligated on the left femoral artery, then the blood perfusion on the hind limbs ischemia was measured by LDPI after the operation. Results The fasting plasma glucose level on 22 Wistar rats(81.5%) was kept above 16.8 mmol/L, and the hind limb blood perfusion would recover slowly to the level of the right side from 1 to 14 day (P
