Oxidative stress and type 2 diabetes
- VernacularTitle:氧化应激与2型糖尿病
- Author:
Fang WANG
;
Yan MENG
- Publication Type:Journal Article
- Keywords:
oxidative stress;
type 2 diabetes;
insulin resistance;
? cell dysfunction
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Insulin resistance and islet ? cell dysfunction are well-identified pathogenesis of type 2 diabetes. The generation of a great quantity of mitochondrial reactive oxygen species (ROS) impairs the function of mitochondria and induces oxidative stress during metabolic process of hyperglycaemia and hyperlipemia. Oxidative stress blocks insulin action pathway and induces insulin resistance; inhibit expression of insulin gene; decrease insulin secretion and impair ? cell function. In this paper, the mechanism of the ROS generation, insulin resistance and ? cell dysfunction induced by oxidative stress are reviewed.
