Increased expression of macrophage migration Inhibitory factor in epithelial and serum in patients with colorectal carcinoma
- VernacularTitle:巨噬细胞移动抑制因子在大肠黏膜癌变患者中表达增强
- Author:
Xingxiang HE
;
Xiaoyu LI
;
Haibo GUO
;
Shizhang HUANG
;
Fuyuan GAO
- Publication Type:Journal Article
- Keywords:
macrophage migration inhibitory factor;
colorectal adenoma;
colorectal carcinoma;
carcinogenesis
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine MIF expression in normal colorectal mucosa,colorectal adenoma and colorectal carcinoma, and the relationship between MIF and the clinical pathologic features of colorectal carcinoma.MethodsMIF expression was determined by immunohistochemical staining ELISA was used to detect the level of MIF in serum samples. Results The percentage of MIF expressing epithelial cells and MIF positive expression intensity were progressively increased in normal colorectal mucosa, colorectal adenoma and colorectal carcinoma. There was significant difference among three groups (P
