Effect of recombinant adenovirus vector containing Hyper-IL-6 on rat model with acute liver failure
- VernacularTitle:Hyper-IL-6重组腺病毒治疗大鼠急性肝衰竭
- Author:
Chuanmin WANG
;
Chunhua QIE
;
Bo QIN
- Publication Type:Journal Article
- Keywords:
acute liver failure;
recombinant adenovirus;
Hyper-IL-6;
liver regeneration;
gene therapy
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effects and mechanisms of Hyper-IL-6 mediated by recombinant adenovirus on rat with acute liver failure(ALF).Methods Eighty ALF rats were randomly divided into 4 groups, normal saline was injected for non-infection group;Ad0,AdIL-6 and AdHIL-6 was respectively injected in group Ad0,group AdIL-6,group AdHIL-6.Subsequently the index of hepatic function, liver pathology, hepatocelluar apoptosis in situ and the expression of PCNA and caspase-3 in liver tissue were examined. The survival rate of rats for 14 days was recorded.Results The level of serum ALT and TB,and apoptotic index in rats of group AdHIL-6 was markedly decreased but expression of PCNA increased (P
