Drug releasing property of two kinds of drug control-released carriers in vitro
- VernacularTitle:两种药物控释载体的体外释药性能
- Author:
Qing DING
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(32):-
- CountryChina
- Language:Chinese
-
Abstract:
Drug control-released carriers are effective to control the dosage and selective release of the drugs in vivo.They have low toxicity,small administration dosage,good biological availability,stability and long half-life period.Drug control-released carriers can be divided into biodegradable high molecular polymer and nano-magnetic materials.High molecular polymer materials mainly comprise polylactic acid copolymer and chitosan,which are nontoxic,harmless,well-biocompatible and completely absorbable,the metabolite has no toxicity.In combination with the chemotherapeutics,the resultant microspheres exhibit good control-released property.Using nano-Fe as magnetic response material,magnetic microspheres wrap the magnetic ultrafine powder and antitumor drug into human albumin or other high molecular substances,so as to prepare a microsphere carrying anticancer drugs of magnetic responseness.It is a new way of target treatment of malignant tumor that target administration is performed in magnetic field in vitro.Although drug control-released carriers have obtained great achievements,clinical application of pharmaceutical preparation is restricted,thus it is a potential study on the target drug control-released system to enhance the design and preparation technology,research and develop a new drug carrier,and prepare intelligent control-released system.
