Effects of different levels of hemodilution during extracorporeal circulation on lactic acid and postoperative outcomes in children with congenital heart disease
- VernacularTitle:小儿先天性心脏病体外循环中血液稀释水平对乳酸和术后转归的影响
- Author:
Xiaobing LI
;
Shuozeng DENG
;
Junchen ZHOU
- Publication Type:Journal Article
- Keywords:
Children;
Extracorporeal circulation;
Hemoglobin;
Lactic acid;
Postoperative outcome
- From:
Chinese Journal of Blood Transfusion
2008;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of different levels of hemodilution during extracorporeal circulation(ECC) on the concentration of lactic acid and postoperative outcome in children with congenital heart disease.Methods Sixty children with congenital heart diseases undergoing open heart surgery with ECC were randomly divided into three groups: groupⅠ(n=20) underwent mild hemodilution [Hb(80—90)g/L],groupⅡ(n=20) with medium hemodilution [Hb(70—79)g/L],and groupⅢ(n=20) with deep hemodilution [Hb(60—69)g/L].The concentration of lactic acid and PaO_2 in groupⅡ and group Ⅲ were compared with groupⅠ before ECC,during ECC,after ECC and 24h after the operation.The rate of homologous transfusion during ECC and the postoperative dosage of furosemide were also compared among the three groups.Results The concentrations of lactic acid and PaO2 in the three groups were all within normal range before ECC,during ECC,after ECC and 24h after operation.The homologous transfusion rate during ECC were lower in groupⅡ(30%)and groupⅢ(15%) compared to that of groupⅠ(50%)(P
