The effect of high-fat diet on IRS-1 and IRS-2 expression of fatty liver in rat
- VernacularTitle:高脂饮食对大鼠脂肪肝胰岛素受体底物1、2表达的影响
- Author:
Shiqing CHEN
;
Hua LI
;
Qi LIU
- Publication Type:Journal Article
- Keywords:
High-fat diet;
Insulin resistance;
Insulin receptor substrate
- From:
Chinese Journal of Diabetes
2008;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of high-fat diet on IRS-1 and IRS-2 expressions of fatty liver in rat. Methods After the rats were fed a high-fat diet (n=7) and a standard chow(n=7) for 8 weeks, insulin sensitivity,lipid metabolism, TNF-? and hepatic mRNA and protein expressions of IRS-1 and IRS-2 were measured. Results Compared with the normal control, the high-fat diet group displayed the elevated levels of insulin resistance,FFA and TNF-?.Hepatic IRS-1 mRNA expression and IRS-1 protein content were reduced by 28% and 32%(P
