Injury apoptosis effects of Endoplasmic reticulum stress on the pancreatic β-cell
10.3760/cma.j.issn.1673-4181.2010.04.010
- VernacularTitle:内质网应激对胰岛β细胞凋亡的损伤效应
- Author:
Wenjia CHEN
;
Libin LIU
- Publication Type:Journal Article
- Keywords:
Endoplasmic reticulum stress;
Pancreatic β-cell;
Cell apoptosis
- From:
International Journal of Biomedical Engineering
2010;33(4):228-230,234
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most sensitive cells of endoplasmic reticulum stress,pancreatic βcells have an abundance of endoplasmic reticulum .It is the adaptive response of pancreatic β cells under Endoplasmic reticulum stress conditions.Internal and external factors in the environment such as oxidative damage,lipid toxicity and the effect of cytokines in the endoplasmic reticulum could breake the steady-state,resulting in barriers to folding or misfolding of protein,thereby to trigger endoplasmic reticulum stress.Serious and lasting stress will lead to β cell apoptosis,involved in a variety of metabohc diseases as well as a variety of diseases.This article gives a review on the injury effects of multi-factor induced endoplasmic reticulum stress on the pancreatic β-cell
