Relationship Between Immediate ?-Lactam Allergy and Polymorphism of Interleukin-10 Gene
- VernacularTitle:白细胞介素10基因-592 C/A和-819 C/T多态性与?-内酰胺类抗菌药物过敏的相关性研究
- Author:
Xinyue LIU
;
Wansheng WEI
;
Chunfeng LI
;
Minghua LU
;
Lan YANG
- Publication Type:Journal Article
- Keywords:
?-Lactam allergy;
Interleukin-10;
Single nucleotide polymorphism
- From:
Chinese Journal of Nosocomiology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the association between 592C/A and-819C/T of interleukin-10 gene polymorphism in patients with immediate ?-lactam drug allergy in Chinese Han population.METHODS The genotype and allele frequency of interleukin-10 gene were studied by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)in 44 Chinese Han patients with evidence of immediate ?-lactam drug allergy and 44 controls subjects.They all matched for sex and atopy,the production was investigated by sequence analysis.RESULTS Our analysis did reveal differences in the distribution of the single nucleotide polymorphism(SNP)between female allergic patients and controls.Among allergy subjects,we found two distinct significant associations between immediate drug allergy women and two linked IL-10 promoter genes polymorphism,-592C/A and-819C/T(P
