Ischemic postconditioning increases the change of hippocampus rCBF and VEGF following cerebral Ischemic in tree shrews
- VernacularTitle:树鼩脑缺血后适应升高海马区rCBF及VEGF的变化
- Author:
Haiyun LUO
;
Shuqing LI
- Publication Type:Journal Article
- Keywords:
photochemistry;
cerebral ischemia;
ischemic postconditioning;
VEGF;
regional cerebral blood flow;
tree shrew
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find the effect and potential mechanism of ischemic postconditioning relief rCBF and VEGF expression during focal cerebral thrombosis.Methods The thrombotic focal cerebral ischemia was induced by photochemical reaction in tree shrews.The rCBF and VEGF expression in hippocampus CA1 area were detected,by laser-Doppler(LD) fowmeter and immunohistochemistry.Results rCBF reduces along with temporal lasting in cerebral thrombus,especially in 24 h;VEGF expression enhanced after cerebral ischemic,express of VEGF in 12 h is the most intensification(P0.05),mostly in 12 h(P
