Significances of Up-expressions of CYCLIND1 and CDK4 in pancreatic carcinoma
- VernacularTitle:CYCLIND1和CDK4在胰腺癌中高表达及其意义
- Author:
Yong YANG
;
Yunning HUANG
;
Gang SU
;
Shijie YANG
;
Baoguo YAO
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
CYCLIND1;
CDK4;
PCNA;
immunohistochemistry
- From:
Basic & Clinical Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of CYCLIND1 CDK4 in pancreatic cancer and their relationship with clinlicopathological parameters.Methods Immunohistochemical detector with new second generational tow steps method was used to detect the expressions of CYCLIND1 CDK4 and PCNA in 48 cases of pancreatic cancer and 14 cases of chronic pancreatitis.Results The expressions of CYCLIND1 CDK4 proteins in pancreatic cancer were 70.85%(34/48)and 62.50%(30/48) respectively.The CYCLIND1 and CDK4 proteins were increased(P
