Inhibition of activated protein kinase C mediated ischemic myocardium protection by polymyxin B sulfate
- VernacularTitle:多黏菌素B阻断蛋白激酶C活化后的缺血心肌保护作用
- Author:
Jinghua LIU
;
Yansheng DING
;
Lu SUN
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning,myocardial;
Action potentials;
Polymyxin B
- From:
Chinese Journal of Interventional Cardiology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the role of protein kinase C(PKC) activation in ischemic myocardium proctection and its effect after inhibition by polymyxin B sulfate.Methods We randomly divided 30 rabbits into ischemic(IS) group,ischemic preconditioning(IPC) group and polymyxin B sulfate(PMB) group.According to the method reported in previous literature,we simultaneously recorded ECG,pressure curve and monophasic action potential(MAP) throughout the ischemia and reperfusion perocess.Results The rabbit heart rates were not changed significantly during the ischemic or reperfusion period.The products of heart rate multiplying systolic pressure were significantly higher in IPC group compared with the other two groups(P
