Role of CD28:CTLA4/B7 costimulatory molecules in experimental autoimmune myasthenia gravis
- VernacularTitle:共刺激分子CD28:CTLA4/B7在实验性自身免疫性重症肌无力中的作用
- Author:
Huaiguo WU
;
Xiaojiang PENG
;
Jun LI
- Publication Type:Journal Article
- Keywords:
myasthenia gravis;
costimulatory molecules;
CD28:CTLA4/B7
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study pathogenesis role of CD28:CTLA4/B7 costimulatory molecules in experimental autoimmune myasthenia gravis(EAMG). Methods Female lewis rats were divided into EAMG group and control group. The rats were immunized thrice with R?97-116 peptide in EAMG group, or only with phosphate buffer saline(PBS) in control group. 5 d after the third immunization, the expressions of CD28,CTLA4,B7-1, B7-2 on the surface of peripheral blood cells, lymphocytes and monocytes were exaimed by flow cytometry. Results In EAMG group,the achievement ratio of EAMG model was 75%; the expressions of CD28,CTLA4,B7-1, B7-2 on the surface of peripheral blood cells were significantly increased than those in control group (P
