Influence of all-trans retinoic acid on the invasive potential of epithelial ovarian carcinoma cell line COC2
- VernacularTitle:全反式维A酸对卵巢上皮性腺癌侵袭潜能的影响
- Author:
Jingxian LIN
;
Qi LIU
;
Yuanzhe WU
;
Xinyi XIA
;
Yan JU
;
Jiandong WANG
- Publication Type:Journal Article
- Keywords:
All-trans retinoic acid;
Epithelial ovarian carcinoma cell;
E-cadherin;
Vascular endothelial growth factor;
Heparanase;
Flow cytometry
- From:
Journal of Medical Postgraduates
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the influence of all-trans retinoic acid(ATRA) on the expressions of E-cadherin,heparanase and VEGF in epithelial ovarian carcinoma cell line COC2,and to investigate the anti-metastatic potential and possible action mechanism of ATRA.Methods: We used flow cytometry to examine the expressions of E-cadherin,heparanase and VEGF proteins in the epithelial ovarian carcinoma cell line COC2 treated with different concentrations of ATRA.Results: ATRA significantly increased the expression of E-cadherin and decrease that of VEGF and hepareanse in a dose-dependent manner.Conclusion: ATRA can inhibit cell proliferation,improve cell-cell adhesion and downregulate the expressions of VEGF and heparanse proteins,suggestive of an anti-angiogenic and anti-metastatic potential.
