Effects of mannose ester on blood lipids,serum oxidized low density lipoprotein,C-reactive protein in patients with coronary heart disease complicated with hyperlipidemia
- VernacularTitle:甘糖酯对冠心病伴高脂血症患者血脂、血清氧化修饰低密度脂蛋白、C-反应蛋白的影响
- Author:
Lijuan TAN
;
Chunling WANG
;
Wengzhong ZHANG
- Publication Type:Journal Article
- Keywords:
mannose ester;
coronary heart disease;
blood lipids;
oxidized low density lipoprotein;
C-reactive protein
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the lipid regulatory effects of mannose ester and its effects on serum oxidized low density lipoprotein(OX-LDL),C-reactive protein(CRP)in patiends with coronary heart disease(CHD)complicated with hyperlipidemia.Methods Seventy-six CHD patients with hyperlipidemia were treated with mannose ester at a dose of 0.1g orally,three times a day for 2 successive months.Levels of blood lipids,OX-LDL,CRP at the time of entry,first month,second month of the therapeutic course were observed.Results Mannose ester could reduce the serum levels of total cholesterol,LDL-C 1 month after medication and the effect was further elevated after 2 months.Meanwhile its effects in lowering triglycerides and increasing high density lipoprotein were observed after 2 months administration.Mannose ester could also significantly lower the serum OX-LDL,CRP after 2 months administration.Conclusion Mannose ester has good regulatory effect on blood lipids,and decreases OX-LDL,CRP.Mannose ester can protect vascular endothelial cells and inhibit the development of inflammation in coronary plaque.Therefore,it can improve the prognosis of CHD patients.
