Antimicrobial Agents Including Cefmetazole Against Extended-spectrum Beta-lactamases-producing Enterobacteriaceae:An in vitro Susceptibility Investigation
- VernacularTitle:产超广谱?-内酰胺酶肠杆菌科对头孢美唑等抗菌药物的体外敏感性分析
- Author:
He WANG
;
Qiwen YANG
;
Yingchun XU
;
Yunjian HU
;
Jingyong SUN
;
Haishen KONG
;
Weiyuan WU
;
Yinmei YANG
;
Shihui GUO
;
Zhenhong ZHU
;
Lixia ZHANG
;
Xuhui ZHU
;
Yaning MEI
;
Zhijie ZHANG
;
Dan LI
;
Pengpeng LIU
;
Lixia PENG
;
Minjun CHEN
- Publication Type:Journal Article
- Keywords:
Cefmetazole;
ESBLs;
Cephamycins;
Drug resistance;
Pathogen
- From:
Chinese Journal of Nosocomiology
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate in vitro activities of 12 antimicrobial agents including cefmetazole against extended-spectrum beta-lactamases-producing Escherichia coli(528 strains),Klebsiella pneumoniae(311 strains) and Proteus mirabilis(15 strains).METHODS They all collected from 15 teaching hospitals in China during 2005 and 2006 and included in the study.The levels of minimal inhibitory concentration(MIC) of 12 antimicrobial agents were determined by agar dilution method.WHONET 5.4 Software was used to analyze the data.RESULTS Against ESBLs-producing E.coli and ESBLs-producing K.pneumoniae,carbapenems were the most active antimicrobial agents(all 100.0% susceptible),followed by cephamycins(80.1-97.3%).Piperacillin/tazobactam(78.5-95.1%)showed a higher activity than cefoperazone/sulbactam(44.1-56.2%).The susceptible rate to ceftazidime against ESBLs-producing E.coli was remarkably higher than the other three cephalosporins,however the differences did not happen to ESBL-producing K.pneumoniae obviously.The susceptible rate to cefuroxime was below 1.6%.ESBLs-producing K.pneumoniae showed high sensitivity to carbapenems,cephamycins and ?-lactam/lactamase inhibitor combinations(all 100% susceptible),however the susceptible rates to cephalosporins were relatively lower.CONCLUSIONS Carbapenems and cephamycins remain the relatively high activity against ESBLs-producing Enterobacteriaceae.
