Heat tolerance obtaining and response of heat shock protein 70 to exercise
- VernacularTitle:热休克蛋白70热耐受性获得与运动应答的反应
- Author:
Wencong HUANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(24):-
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND: Heat shock protein70 (HSP70) can improve body's ability for high temperature tolerance, and protect cell structure induced by various stresses, such as energy loss and ischemia, which all means HSP70 is the basic of body survive in normal and high temperatures. OBJECTIVE: To summarize the mechanism of HSP70 heat tolerance obtaining and the cause of HSP70 different responses to different exercises. RETRIEVAL STRATEGY: A computer-based search of PubMed database and Wanfang database was undertaken to identify the articles published from January 1994 to October 2007 with the keywords of "HSP70, Heat Tolerance, Sports Stress" in both Chinese and English. Totally 533 articles were retrieved manually. Inclusive criteria: ①original articles with reliable arguments and evidences, ②articles with clear viewpoint and all-round analysis, ③main contents of the articles were closely connected with this topic. Excusive criteria: articles with unreasonable design and reviews with indefinite viewpoint. Totally 166 articles met the inclusive criteria were included. After the document refinement, 5 Chinese articles and 32 English articles were involved. LITERATURE EVALUATION: Totally 166 article were classified and sorted, and 37 of them served as references, including 8 review articles and 29 human and animal experiments, which was consisted of 12 articles of HAP70 heat tolerance and regulation, 17 articles of the exercise and HSP70 response. DATA SYNTHESIS: The cells of all tissues react to various stresses through the quick synthesization of HSPs. As the most important HSPs family, HSP70 has the highest temperature sensitivity and conservation. Many studies have proved that, HSP70 can improve the cell or organism's ability of heat tolerance, and protect the cell structure induced by various stresses, such as heat stress, hypoxia and infection. Acute exercise induces HSP70 increasing, and the response of HSP70 may depend on the exercise intensity; While a long-term training decreases HSP70's response to acute exercise, which may mean the adaption of body to exercise. CONCLUSION: HSP70 can make the cell obtaining heat tolerance when the stress comes again, through chaperones function, anti-oxidation function, cooperating with immunity function and anti-apoptosis function, which is a possible reason for the adaption of bodies to the long-term training. Acute exercise and long-term training may have different effects on HSP70 response, and age may be an important factor.
