Progress of tissue-engineered blood vessels
- VernacularTitle:组织工程血管的研究进展
- Author:
Di TAI
;
Wei REN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Vascular bypass grafting is the most common procedure for ischemic heart disease and peripheral vascular disease. Although synthetic grafts have been developed, replacement of vessels with purely synthetic polymeric conduits often leads to the failure of such graft, especially in the grafts less than 6 mm in diameter, mainly due to the early formation of thrombosis, infection and so on. Tissue engineering is a relatively new discipline that offers the potential to create vascular grafts from autologous cells and biodegradable polymer scaffolds. It has become a promising approach for generating a biocompatible vessel graft and contributing to the long-term patency rate of small-caliber grafts. This review describes the major progress in the tissue engineering vascular grafts, including the seeding cell sources, the biodegradable scaffolds, the construction technologies of tissue-engineered vessels, as well as nanotechnology.
