Effect of candesartan on ERK1/2 protein expression in myocardium of epilepsy rats induced by kainic acid and its mechanism
- VernacularTitle:坎地沙坦干预KA致痫大鼠心肌细胞ERK1/2的表达及其机制
- Author:
Suisheng WU
;
Zan WANG
;
Li PANG
;
Linquan WANG
- Publication Type:Journal Article
- Keywords:
candesartan;
epilepsy;
myocardium;
ERK1/2;
kainic acid
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of candesartan on the ERK1/2 protein expression in myocardium of epilepsy rats induced by kainic acid(KA) and its mechanism.Methods 105 male Wistar rats were divided into: control group(A);epilepsy groups(B1-5);candesartan groups(C1-5);1-5 meaned 0,0.5,2,4,6 h after epilepsy,respectively.Epilepsy rat models were made by injecting KA into amygdale under stereotactic instrument.The ERK1/2 protein expression in various groups were tested with immunohistological method.Results Compared with control group,the protein expressions of ERK1/2 increased significantly in the 0.5 h groups of B and C(P0.05).The differences in the level of ERK1/2 protein expression between B and C groups were significant(P
