Expressions of matrix metalloproteinase 8 mRNA in apical granuloma and periapical cyst and their significances
- VernacularTitle:基质金属蛋白酶8mRNA在根尖肉芽肿和根尖囊肿组织中的表达及其意义
- Author:
Jianfang CHEN
;
Xiaochun HU
;
Yingli ZHANG
- Publication Type:Journal Article
- Keywords:
radicular cyst;
neitrophil collagenase;
reverse transcriptase polymerase chain reaction
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the role of matrix metalloproteinase-8(MMP-8) mRNA in apical granuloma and periapical cyst by detecting the its expressions in the periapical granuloma and periapical cyst.Methods Reverse transcription polymerase chain reaction(RT-PCR) technique was used to measure the expressions of MMP-8 mRNA in 22 cases of periapical granuloma,11 cases of periapical cyst and 10 cases of normal periapical tissues.Results The positive rates and the levels of MMP-8 mRNA expression in apical granulomas and periapical cysts were significantly higher than those in normal tissues(P0.05).Conclusion The expression of MMP-8 may play an important role in the pathogenesy of apical granuloma and periapical cyst,and it may be involved in the process of bone destruction.
