Expression and distribution of VLDLR and its subtypes in various tissues of type 2 diabetic rat
- VernacularTitle:极低密度脂蛋白受体及其亚型在2型糖尿病大鼠组织中的分布与表达
- Author:
Tingting SUN
;
Muxun ZHANG
;
Yongping XU
- Publication Type:Journal Article
- Keywords:
Receptors,VLDL;
Gene expression;
Diabetes mellitus,type 2
- From:
Chinese Journal of Diabetes
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and expression of total amount and two subtypes of very low density lipoprotein receptor(VLDLR)in various tissues(heart,cerebrum,kidney,muscle,adipose)of normal SD rats and type 2 diabetic SD rats.Methods The mRNA of VLDLR from various tissues were amplified by semi-quantitative RT-PCR.Results The expression levels of VLDLR were reduced in all collected tissues compared with normal ones,especially in cerebrum,kidney,muscle,adipose(P
