Detection and clinical significance of uPAR in tissue and plasma of patients with cervical carcinoma
- VernacularTitle:子宫颈癌患者血清及组织中纤溶酶原蛋白激活物受体的检测及其临床意义
- Author:
Pei WANG
;
Shumin ZHENG
;
Jiexian JING
;
Yongfeng GUO
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Immunohistochemistry;
Tissue plasminogen activator
- From:
Cancer Research and Clinic
2008;20(7):474-475,478
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship uPAR in tissue and plasma of patients with cervical carcinoma and its clinical pathophysiological characteristics. Methods The preoperative plasma cancer tissue and its adjacent tissue in 42 cases of patient with ⅠB～ⅡA cervical carcinoma and the preoperative plasma and postoperative cervical tissue in 30 cases of patient with hysteromyoma were collected. Their uPAR were detected by ELISA. Results uPAR in the plasma of patients with cervical carcinoma was significantly higher than those in healthy controls and in patients with hysteromyoma. It was related to tumor invasive depth and lymph node metastasis and not related to tumor differentiation, uPAR in cancer tissue of patients with cervical carcinoma was significantly higher than those in normal cervical tissue. It was related to tumor differentiation and not to tumor invasive depth and lymph node metastasis. Conclusion uPAR in the plasma of patients with cervical carcinoma is related to invasion and metastasis, uPAR in the tissue is related to tumor differentiation.
