Lamivudine for Prophylaxis Against Hepatitis B Virus Reinfection Following Orthotopic Liver Transplantation:An Clinical Analysis
- VernacularTitle:拉米夫定预防肝移植后乙型肝炎病毒再感染的临床分析
- Author:
Xianjie SHI
;
Wenbin JI
;
Weidong DUAN
;
Jianjun LENG
;
Hongguang WANG
;
Yongbing CHEN
;
Jiahong DONG
;
Zhiqiang HUANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Hepatitis B virus;
Lamivudine
- From:
Chinese Journal of Nosocomiology
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the effect of lamivudine on prophylaxis against hepatitis B virus(HBV) reinfection following orthotopic liver transplantation(OLT).METHODS The clinical data of 14 CLT recipients with HBV-related diseases received lamivudine(100mg/day) were retrospectively analyzed in our hospital.Hepatitis B serum markers,serum HBVDNA,and YMDD district variation were detected every two weeks.HBsAg and HBcAg in the liver specimens were examined by immunohistochemistry.Liver biopsy was conducted from the donor during operation and from the recipient postoperatively in a regular interval.RESULTS The reinfection took place in 4 patients and postoperatively(28.6%),HBV-DNA was transfered to the positive in 2 cases,and among them was 1 YMDD district produced and made a variation. Two cases with positive HBV-DNA before liver transplantation had higher HBV reinfection rate postoperatively.CONCLUSIONS Lamivudine monotherapy can effectively and definitely;preven HBV reinfection after liver transplantation HBV reinfection can produce YMDD district and make a variation again;HBV relevant diseases patient should negatively turn the HBV-DNA at the time of competent liver transplantation.
