TRAIL and DR5 contribute to the development of atherosclerosis
- VernacularTitle:TRAIL及其受体DR5参与动脉粥样硬化的发生
- Author:
Manyi REN
;
Shujian SUI
;
Yun ZHANG
;
Fuyu XU
;
Weihong MA
- Publication Type:Journal Article
- Keywords:
TNF related apoptosis inducing ligand;
receptor;
atherosclerosis;
apoptosis;
immunohistochemistry
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the level of tumor necrosis factor related apoptosis inducing ligand(TRAIL) and death receptor 5(DR5) and atherosclerosis(AS).Methods Eighty-three patients were divided into two groups: Sixty-one in the coronary artery disease(CAD) group and 22 in normal coronary artery group.Plasma soluble TRAIL(sTRAIL) and soluble DR5(sDR5) levels from these people were assayed by ELISA.The level of TRAIL and DR5 protein expression in coronary arteries were detected by immunohistochemisty statining.Results Plasma sTRAIL and sDR5 significantly increased in the CAD group(P
