Protective effect of prostaglandin E1 on platelet during cardiopulmonary bypass
- VernacularTitle:先天性心脏病患儿血管内皮生长因子单核苷酸多态性研究
- Author:
Yonghua SANG
;
Yijiang CHEN
;
Haiyong GU
;
Liang CHEN
- Publication Type:Journal Article
- Keywords:
prostaglandin E1;
cardiopulmonary bypass;
thromboxane B2 (TXB2);
6-keto-prostaglandin F1?(6-K-PGF1?);
ultrastructure of platelet
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of prostaglandin E1 (PGE1) on platelet during cardiopulmonary bypass (CPB).Methods A total of 24 patients undergoing cardiac valve replacement were randomly divided into the experimental group (n=12) and the control group (n=12).The levels of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1?(6-K-PGF1?) in serum were measured at different intervals during and after CPB. The ultrastructure of platelets was also observed by transmission electron microscope.Results The levels of TXB2 and 6-K-PGF1? during CPB were significantly higher than those before CPB in the both groups(P
