Dexamethasone inhibits expression of aquaporin-4 of non-pigmented ciliary epithelium in rabbit
- VernacularTitle:地塞米松抑制兔眼睫状体无色素上皮水通道-4蛋白的表达
- Author:
Jing DU
;
Yueqiang FU
;
Su LIU
- Publication Type:Journal Article
- Keywords:
dexamethasone;
non-pigmented ciliary epithelial cell;
quaporin-4;
glaucoma
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of dexamethasone(Dex) on expression of aquaporin-4(AQP4) in rabbit non-pigmented ciliary epithelium(NPCE).Methods To construct rabbit corticosteroid-induced glaucoma model and then compare the differences of AQP4 expression in NPCE with normal controls by immunohistochemistry and immunofluorescence methods,as well as Western blot method.Results The immunohistochemistry results indicated that the AQP4 expression in NPCE of DEX group(OD=0.119?0.072) was suppressed(0.242?0.056)(P
