A Novel Aromatic Fluorine-18 Labeling Method Using Iodonium Salts Precursor.
- Author:
Byung Seok MOON
1
;
Byung Chul LEE
;
Sang Eun KIM
Author Information
1. Institute of Radiation Medicine, Seoul National University Medical Research Center & Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. leebc@snu.ac.kr
- Publication Type:Review
- Keywords:
Aromatic fluorination;
fluorine-18;
diaryliodonium salts;
PET
- MeSH:
Electrons;
Fluorine;
Halogenation;
Salts
- From:Nuclear Medicine and Molecular Imaging
2009;43(1):1-9
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
As many new drug substances contained various aromatic rings and fluorine attached to an electron rich aromatic ring or on the meta-position, a strategy towards improvement in aromatic fluorination of these compounds is highly desirable. The introduction of fluorine-18 onto aromatic rings showed in the limited condition containing electron withdrawing group (EWG) on the para- or ortho-position to get reasonable radiochemical yield so far. No-carrier added (NCA) [18F]fluoroarene syntheses by iodonium salts recently reported that has the potential to greatly increase the yield in systems or positions that normally not reactive enough to give sufficient yields in simple model reaction. This review describes the methodological approach towards effective aromatic fluorination by diaryliodonium salts and future prospects in an application of novel PET radiotracer.
