Evaluation of Multiple System Atrophy and Early Parkinson's Disease Using (123)I-FP-CIT SPECT.
- Author:
So Won OH
1
;
Yu Kyeong KIM
;
Byung Chul LEE
;
Bom Sahn KIM
;
Ji Sun KIM
;
Jong Min KIM
;
Sang Eun KIM
Author Information
1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Korea. yk3181@snu.ac.kr
- Publication Type:Original Article
- Keywords:
(123)I-FP-CIT;
SPECT;
dopamine transporter;
serotonin transporter;
idiopathic Parkinson's disease;
multiple system atrophy
- MeSH:
Atrophy;
Brain;
Dopamine Plasma Membrane Transport Proteins;
Humans;
Hypothalamus;
Mesencephalon;
Multiple System Atrophy;
Parkinson Disease;
Parkinsonian Disorders;
Pons;
Putamen;
Serotonin Plasma Membrane Transport Proteins;
Tomography, Emission-Computed, Single-Photon;
Tropanes
- From:Nuclear Medicine and Molecular Imaging
2009;43(1):10-18
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated quantification of dopaminergic transporter (DAT) and serotonergic transporter (SERT) on (123)I-FP-CIT SPECT for differentiating between multiple systemic atrophy (MSA) and idiopathic Parkinson's disease (IPD). MATERIALS AND METHODS: N-fluoropropyl-2beta-carbomethoxy-3beta-4-[(123)I]-iodophenylnortropane SPECT ((123)I-FP-CIT SPECT) was performed in 8 patients with MSA (mean age: 64.0+/-4.5yrs, m:f=6:2), 13 with early IPD (mean age: 65.5+/-5.3yrs, m:f=9:4), and 12 healthy controls (mean age: 63.3+/-5.7yrs, m:f=8:4). Standard regions of interests (ROIs) of striatum to evaluate DAT, and hypothalamus and midbrain for SERT were drawn on standard template images and applied to each image taken 4 hours after radiotracer injection. Striatal specific binding for DAT and hypothalamic and midbrain specific binding for SERT were calculated using region/reference ratio based on the transient equilibrium method. Group differences were tested using ANOVA with the postHoc analysis. RESULTS: DAT in the whole striatum and striatal subregions were significantly decreased in both patient groups with MSA and early IPD, compared with healthy control (p<0.05 in all). In early IPD, a significant increase in the uptake ratio in anterior and posterior putamen and a trend of increase in caudate to putamen ratio was observed. In MSA, the decrease of DAT was accompanied with no difference in the striatal uptake pattern compared with healthy controls. Regarding the brain regions where (123)I-FP-CIT binding was predominant by SERT, MSA patients showed a decrease in the binding of (123)I-FP-CIT in the pons compared with controls as well as early IPD patients (MSA: 0.22+/-0.1 healthy controls: 0.33+/-0.19, IPD: 0.29+/-0.19), however, it did not reach the statistical significance. CONCLUSION: In this study, the differential patterns in the reduction of DAT in the striatum and the reduction of pontine (123)I- FP-CIT binding predominant by SERT could be observed in MSA patients on (123)I- FP-CIT SPECT. We suggest that the quantification of SERT as well as DAT using (123)I- FP-CIT SPECT is helpful to differentiate parkinsonian disorders in early stage.
