Diffuse Hypermetabolism at Bone Marrow in F-18 FDG PET/CT: Correlation with Bone Marrow Biopsy and Complete Blood Cell Counts.
- Author:
Yun Hee KANG
1
;
Seok Tae LIM
;
Young Jin JEONG
;
Dong Wook KIM
;
Hwan Jeong JEONG
;
Myung Hee SOHN
Author Information
1. Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Korea. stlim@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Bone marrow;
PET/CT;
bone marrow biopsy;
complete blood cell counts;
FDG
- MeSH:
Anemia;
Biopsy;
Blood Cell Count;
Blood Cells;
Blood Platelets;
Bone Marrow;
Bone Marrow Examination;
Eosinophils;
Erythropoietin;
Granulocyte Colony-Stimulating Factor;
Hemoglobins;
Humans;
Hyperplasia
- From:Nuclear Medicine and Molecular Imaging
2009;43(1):35-39
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Increased FDG uptake in the bone marrow has been reported in patients taking erythropoietin or granulocyte-colony stimulating factor (G-CSF). The aim of this study is to investigate the correlation between F-18 FDG uptake in the bone marrow and bone marrow finding, hematological parameters. MATERIALS AND METHODS: Twenty patients who had diffuse FDG uptake at the bone marrow and received hematological examinations, bone marrow biopsy within 10 days before or after PET/CT were enrolled in this study. Among them, 11 patients were excluded; 4 patients received G-CSF or erythropoietin before PET/CT. Seven patients showed definite pathology in a bone marrow biopsy. The parameters included the measurement of WBC, hemoglobin, platelet and cellularity of the bone marrow. RESULTS: Bone marrow FDG uptake was correlated with a low hemoglobin but not WBC, platelet. Histopathologic findings in marrow biopsies were various: normal finding (n=3), hyperplasia of granulocytic cells (n=2), eosinophilic hyperplasia (n=1), reactive lymphoid nodules (n=1), hypercelluar marrow (n=1), hypocelluar marrow (n=1). All patients except two, showed normal marrow celluarity. CONCLUSION: FDG uptake by bone marrow correlated with anemia but not WBC, platelet, bone marrow cellularity.
