Comparison of FDG Uptake with Pathological Parameters in the Well-differentiated Thyroid Cancer.
- Author:
Woo Hee CHOI
1
;
Yong An CHUNG
;
Ki Jun KIM
;
Chang Suk PARK
;
Hyun Suk JUNG
;
Hyung Sun SOHN
;
Soo Kyo CHUNG
;
Chang Young YOO
Author Information
1. Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea. nm@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Thyroid cancer;
F-18 FDG;
PET/CT
- MeSH:
Carcinoma, Papillary;
Galectin 3;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Thyroid Gland;
Thyroid Neoplasms;
Thyroiditis
- From:Nuclear Medicine and Molecular Imaging
2009;43(1):40-47
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Differentiated thyroid cancer (DTC) has variable degree of F-18 FDG avidity. The purpose of this study was to evaluate the relationship between F-18 FDG uptake and pathological or immunohistochemical features of DTC. MATERIALS AND METHODS: DTC patients who underwent both pre-operative F-18 FDG PET/CT scan and surgery were included in the study. Maximum standardized uptake values (SUVmax) of primary tumor were calculated. If the primary tumor showed no perceptibly increased F-18 FDG uptake, region of interest was drawn based on finding of CT portion of the PET/CT images. Pathological and immunohistochemical markers such as presence of lymph node (LN) metastasis and underlying thyroiditis, tumor size, Ki-67 labeling index, expressions of EGFR, COX-2, and Galectin-3 were evaluated. RESULTS: Total of 106 patients was included (102 papillary carcinomas, 4 follicular carcinomas). The mean SUVmax of the large tumors (above 1 cm) was significantly higher than the mean SUVmax of small (equal to or less than 1 cm) ones (7.8+/-8.5 vs. 3.6+/-3.1, p=0.004). No significant difference in F-18 FDG uptake was found according to the presence or absence of LN metastasis and underlying thyroiditis, or the degree of Ki-67 labeling index, expression of EGFR, COX-2 and Galectin-3. CONCLUSION: In conclusion, the degree of F-18 FDG uptake in DTC was associated with the size of primary tumor. But there seem to be no relationship between F-18 FDG uptake of DTC and expression of Ki-67, EGFR, COX-2 and Galectin-3.
