Changes of ultrastructure and Bax,Bcl-2 expression of rat brain in lymphostatic encephalopathy
- VernacularTitle:淋巴滞留性脑病大鼠脑组织超微结构及Bax、Bcl-2表达的变化
- Author:
Yuxian LI
;
Jun ZHANG
;
Hongjun SHI
- Publication Type:Journal Article
- Keywords:
lymphostatic encephalopathy;
Bax;
Bcl-2
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of ultrastructure and Bax,Bcl-2 expression of cerebral cortex in lymphostatic encephalopathy(LE).Methods LE models were established by occluding and removing both the shallow and deep cervical lymph nodes in rats.Ultrastructural changes of the cerebral cortex were observed at 1 d,2 d,3 d,5 d,7 d and 14 d after operation.Expression of Bax and Bcl-2 were examined by Western blot.Results Brain edema appeared under electron microscope in LE model group.The perivascular spaces in the cortex were enlarged and full of fluid,the dropsical nerve fibers had swelling and fragmented myelin sheath.Some neurons showed apoptotic conformation and some had characters of necrosis.The changes mentioned above were the most serious at day 5.The protein expression of Bax,Bcl-2 and the ratios of Bax/Bcl-2 in LE 3 d,5 d,7 d groups were significantly higher than those in normal control group(all P
