Changes of expression levels of vascular endothelial growth factor and its receptors in diabetes rats with cerebral infarction
- VernacularTitle:糖尿病脑梗死大鼠血管内皮生长因子及其受体表达水平的变化
- Author:
Xiaoyun XU
;
Gang LI
- Publication Type:Journal Article
- Keywords:
diabetes;
cerebral infarction;
vascular endothelial growth factor;
FLT-1;
FLK-1
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of expression levels of vascular endothelial growth factor(VEGF) and its receptors(FLT-1,FLK-1) mRNA in equal area of penumbra in diabetes rats with cerebral infarction(DMCI).Methods Middle cerebral artery occlusion(MACO) model was made in diabetes rats.The expression levels of VEGF and FLT-1,FLK-1 mRNA in equal area of penumbra were measured with situ hybridization in different times after MACO(1 h,3 h,6 h,12 h,24 h).The difference was compared between DMCI group and no diabetes cerebral infarction(NDMCI) group.Results The expression level of VEGF mRNA was lower in DMCI group than that of NDMCI group at every time point(P
