Effects of Cocain and amphetamine-regulated transcript peptides on ischemic brain damage and Caspase-3 activity of neurons

VernacularTitle:可卡因-苯丙胺调节转录肽对缺血性脑损伤及其神经元半胱天冬氨酸蛋白酶活性的影响
Author: Xuemei CHEN ; Jia JIA ; Yun XU
Publication Type:Journal Article
Keywords: Cocain and amphetamine-regulated transcript peptides; cerebral ischemic; Caspase-3
From: Journal of Clinical Neurology 1988;0(02):-
CountryChina
Language:Chinese
Abstract: Objective To investigate effects of Cocain and amphetamine-regulated transcript(CART) peptides on cerebral ischemic damage and Caspases-3 activities of neurons.Methods 12 mice were randomly divided into CART group and the control group.Mice model of cerebral ischemic was made,after CART group was lateral ventricle injected CART peptides,control group was lateral ventricle injected saline water.Infarction volume was detected by TTC staining.Viability rate of OGD-neurons with CART peptides or salinewater,after mice cortical neuron in vitro was detected by MTT.Caspases-3 activitie was measured by ELISA.Results Infarction volume in the CART group [(0.225?0.044)mm3] was significantly smaller than that in the control group [(0.389?0.055)mm3](P