Change of glycogen synthase kinase-3 activity in lymphocytes in patients with mild cognition impairment
- VernacularTitle:轻度认知功能障碍患者淋巴细胞糖原合成酶激酶-3活性的变化
- Author:
Liang LI
;
Jianhua WANG
;
Zhongsen QU
- Publication Type:Journal Article
- Keywords:
mild cognition impairment;
lymphocyte;
glycogen synthase kinase-3
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of glycogen synthase kinase-3(GSK-3) activity in lymphocytes in patients with mild cognition impairment(MCI).Methods The phosphorylation of GSK-3? at Ser 9 site and total level of GSK-3? in peripheral blood were measured by Western-blot in normal control group,one-year MCI group,two-year MCI group and three-year MCI group.Results The phosphorylation of GSK-3? at Ser 9 site were lower in 1-year MCI group,2-year MCI group and 3-year MCI group,compared with normal control group(all P0.05).Conclusion The activity of GSK-3 in lymphocytes in MCI patients is raised,which implies a subsidiary value of MCI diagnosis.
