Influence of Erythropoietin on cognition,brain protection and ?-tubulin expression in hippocampus in vascular dementia rat models
- VernacularTitle:促红细胞生成素对血管性痴呆模型大鼠认知功能、脑保护作用及海马?-微管蛋白表达的影响
- Author:
Peiyan SHAN
;
Jing GAO
;
Yan JI
- Publication Type:Journal Article
- Keywords:
Erythropoietin;
dementia;
vascular;
Morris water maze;
?-tubulin
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of Erythropoietin(Epo) on cognition,brain protection and ?-tubulin expression in hippocampus in rat models of vascular dementia(VD).Methods VD rat models were established by two-vessel occlusion and salium nitroprusside.Epo group was treated by intraperitoneal injection of Epo.Morris labyrinth test was performed to detect the cognition of rats.Nissle staining and ?-tubulin immunohistochemistry staining were used to observe the cellular morphous.Western blot method was used to assay ?-tubulin contents in hippocampus.The results of Epo group were compared with those of VD models(VD group) and sham-operative group.Results Compared with VD group,Epo group had significantly shorter the escaping latency of Morris labyrinth(excepting the first day of the test)(all P
